The Martin Lab is currently investigating the effects of mutations on the function of the SARS-CoV-2 Main Protease (Mpro). In collaboration with the Butts Lab, a paper was recently published in Biochemistry (https://doi.org/10.1021/acs.biochem.0c00462). In this paper we were able to characterize the sequences of 78 clinically relevant Mpro sequences. These sequences shed light on the mutational landscape and offer insight on how these mutations affect the active site of this cysteine protease. Mpro plays an important role in the viral replication process of SARS-CoV-2 by cleaving proteins in highly specific regions inside the large polyproteins 1a and 1ab.